Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.6K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.4K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.8K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.8K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

3.6K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
3.6K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.6K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Statins and primary liver cancer: a meta-analysis of observational studies.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)·2012
Same author

Lung cancer mortality in European women: trends and predictions.

Lung cancer (Amsterdam, Netherlands)·2012
Same author

Tobacco control: economic aspects of smoking.

Preventive medicine·2012
Same author

Time to first cigarette and upper aerodigestive tract cancer risk in Japan.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2012
Same author

Re: coffee consumption and prostate cancer risk and progression in the health professional follow-up study.

Journal of the National Cancer Institute·2012
Same author

Italy SimSmoke: the effect of tobacco control policies on smoking prevalence and smoking attributable deaths in Italy.

BMC public health·2012

Related Experiment Video

Updated: Jan 11, 2026

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
10:16

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

50.7K

Microplastics and cancer.

Giorgio Bogani1, Erica Trimarchi1, Valentina Chiappa1

  • 1Department of Surgery, Gynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|November 17, 2025
PubMed
Summary
This summary is machine-generated.

Microplastics (MPs) are found in human tissues and tumors, raising health concerns. While MPs may contribute to cancer development and progression, direct causal evidence in humans is currently lacking.

Keywords:
cancerchemoresistancehealthmicroplasticsoxidative stress

More Related Videos

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell
08:11

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell

Published on: August 14, 2021

5.0K
Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris
05:31

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Published on: July 28, 2018

16.7K

Related Experiment Videos

Last Updated: Jan 11, 2026

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis
10:16

Protocol for Microplastics Sampling on the Sea Surface and Sample Analysis

Published on: December 16, 2016

50.7K
Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell
08:11

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell

Published on: August 14, 2021

5.0K
Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris
05:31

Sampling, Sorting, and Characterizing Microplastics in Aquatic Environments with High Suspended Sediment Loads and Large Floating Debris

Published on: July 28, 2018

16.7K

Area of Science:

  • Environmental Health
  • Toxicology
  • Oncology

Background:

  • Microplastics (MPs) are widespread environmental pollutants detected in various human tissues and body fluids.
  • MPs can carry toxic substances and induce cellular damage, including oxidative stress and inflammation, which are implicated in cancer.
  • Recent findings show higher MP concentrations in human tumors compared to healthy tissues.

Purpose of the Study:

  • To review the potential role of microplastics in human cancer pathogenesis.
  • To explore the association between MP exposure and cancer risk, progression, and treatment resistance.

Main Methods:

  • Literature review of experimental studies and recent findings on microplastics in human tissues and tumors.
  • Analysis of potential oncogenic mechanisms, including MP-induced cellular alterations and their role as vectors for carcinogens.

Main Results:

  • Microplastics have been detected in human lungs, colon, blood, placenta, and tumors.
  • MPs may promote cancer development by inducing inflammation, genotoxicity, and altering metabolic processes.
  • Associations observed between MPs and increased colorectal cancer risk, chemoresistance, and reduced survival in lung adenocarcinoma patients.

Conclusions:

  • Biologically plausible mechanisms link microplastic exposure to cancer pathogenesis.
  • Further clinical and epidemiological studies are needed to establish a causal association between microplastics and human cancer.