Berberine-cucurbit[7]uril complex boosts the antitumor effect of berberine
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Fengjiao Xu1,2, Mengying Zhong1,2, Xue Xiao1,2
1Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, Hunan Normal University, Changsha, Hunan, China.
Abstract:
This study successfully constructed and systematically characterised a host-guest complex (Q[7]/BH) based on cucurbit[7]uril (Q[7]) and berberine (BH), which significantly enhanced the antitumor efficacy of BH. Nuclear magnetic resonance, infra-red spectrometry, and fluorescence spectra analysis confirmed the formation of a stable 1:1 inclusion complex (Q[7]/BH) through host-guest interactions. In vitro cell experiments proved that Q[7]/BH had an inhibitory effect on various cancer cells, and in vivo antitumor results showed that Q[7]/BH significantly increased anticancer activity compared with BH. This work provides a supramolecular encapsulation strategy for optimising the activity of natural products.
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