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Does oXiris Matter? A Comparative Outcome Study in Continuous Renal Replacement Therapy-Treated Septic Intensive Care
Payam Rahimi1, Furkan Tontu2, Batoul Khoundabi3
1Anesthesiology and Intensive Care, University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, payam.rahimi@saglik.gov.tr.
Blood Purification
|November 17, 2025
Summary
The oXiris hemofilter improved survival in sepsis patients requiring continuous renal replacement therapy (CRRT). Despite higher initial inflammatory markers, oXiris use was linked to better ICU survival and shorter CRRT duration.
Area of Science:
- Nephrology
- Critical Care Medicine
- Infectious Diseases
Background:
- Sepsis often causes acute kidney injury, necessitating continuous renal replacement therapy (CRRT).
- The oXiris hemofilter's adsorptive properties for cytokines and endotoxins may improve sepsis outcomes, but evidence is limited.
- This study evaluated the clinical impact of oXiris versus standard filters in septic ICU patients undergoing CRRT.
Purpose of the Study:
- To compare the clinical outcomes of septic ICU patients treated with CRRT using oXiris versus standard filters.
- To assess the effect of oXiris on ICU mortality, length of stay, and inflammatory markers.
Main Methods:
- A retrospective observational study of 360 adult septic patients in a tertiary ICU.
- Patients received either oXiris or standard CRRT filters (M-100/M-150) for at least 16 hours.
- Primary endpoint was ICU mortality; secondary endpoints included ventilator-free days (VFDs) and ICU length of stay.
Main Results:
- Despite higher baseline SOFA scores and inflammatory markers (CRP, PCT, lactate), the oXiris group showed significantly higher ICU survival (61.7% vs. 48.9%, p=0.019).
- oXiris use was independently associated with improved survival (OR 1.68, 95% CI 1.09-2.60, p=0.020) and markedly shorter CRRT duration (56.4 vs. 107.4 h, p<0.001).
- Hemodynamic stabilization was more pronounced with oXiris, though inflammatory markers remained elevated and platelet counts decreased in both groups.
Conclusions:
- The oXiris filter was associated with significantly higher ICU survival rates in sepsis patients undergoing CRRT.
- Persistent elevations in CRP and PCT, and thrombocytopenia, suggest these markers may not fully reflect therapeutic response.
- Further randomized trials are necessary to confirm oXiris efficacy and address potential confounders.
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