Related Experiment Video
Updated: Jan 11, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Insomnia disorder and cerebrospinal fluid markers of dementia
Philip Gehrman1,2, Terry McDonald3, Holly Barilla1
1Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.
Abstract:
Sleep disturbance may increase risk of Alzheimer's disease and related dementias (ADRD). Acute sleep deprivation increases cerebrospinal fluid (CSF) levels of amyloid-β, but the impact of chronic insomnia remains unclear. We compared 13 adults aged 30-60 with Insomnia Disorder to matched good sleepers. After overnight polysomnography a lumbar puncture was performed to collect CSF for assays of ADRD biomarkers. Contrary to our hypotheses, we found no significant differences in objective sleep measures or any CSF biomarkers, except for lower levels of neurofilament light. These findings suggest that mild-to-moderate Insomnia Disorder may not increase ADRD biomarkers, contrasting with effects of acute sleep deprivation.
More Related Videos
07:08A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
Related Concept Videos
Insomnia
Multiple factors contribute...
Dementia
The progression of dementia is generally gradual....
REM Sleep Behavior Disorder
RBD is significantly associated with...
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Management of Insomnia
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge: