Progression in adult patients with early-stage chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania: prospective longitudinal study
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View abstract on PubMed
Summary
This summary is machine-generated.Progression of early-stage chronic kidney disease (CKD) affects 28% of adult patients in Tanzania. Key predictors include diabetes mellitus, proteinuria, anemia, and use of local herbs.
Area Of Science
- Nephrology
- Public Health
- Internal Medicine
Background
- Chronic kidney disease (CKD) is a growing global health concern.
- Early-stage CKD management is crucial to prevent disease progression and associated complications.
Purpose Of The Study
- To determine the progression rate of early-stage chronic kidney disease (CKD) in adult patients.
- To identify predictors of CKD progression in a Tanzanian tertiary hospital setting.
Main Methods
- A prospective longitudinal study was conducted in two tertiary hospitals in Dodoma, Tanzania.
- 352 adult patients (≥18 years) with early-stage CKD (eGFR ≥30 mL/min/1.73 m²) were enrolled from November 2020 to March 2022.
- CKD progression was assessed after 12 months of follow-up.
Main Results
- The prevalence of CKD progression was 28.0% (97/346) after 12 months.
- Significant predictors of CKD progression included diabetes mellitus (OR=7.02), use of local herbs (OR=27.98), anemia (OR=2.49), and proteinuria (OR=7.51).
- Among patients with CKD progression, 52.5% had left ventricular hypertrophy (LVH), and 26.8% had coronary artery disease (CAD).
Conclusions
- A substantial proportion of adult patients with early-stage CKD experienced disease progression within 12 months.
- Diabetes mellitus, proteinuria, anemia, and use of local herbal medicines are significant predictors of CKD progression.
- CKD progression is associated with a high burden of cardiovascular complications, including LVH and CAD.
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