Bionic meta microneedle photonic crystal patch for advanced wound care

Chronic wounds remain difficult to manage due to unstable adhesion, uncontrolled therapy, and the absence of real-time monitoring. Here, we present a bionic meta microneedle photonic crystal patch that integrates robust tissue adhesion, spatiotemporal drug delivery, and optical biosensing in a single platform. The patch combines drug-loaded biodegradable microneedles with a micropillar-inspired interface to establish a tissue-mimetic three-dimensional contact, ensuring secure attachment on moist and dynamic skin surfaces. Embedded photonic crystal structures function as high-sensitivity optical sensors, enabling continuous, noninvasive monitoring of wound parameters infection-related metabolites. In a chronic wound mouse model, the patch significantly accelerated healing by inhibiting bacterial proliferation, attenuating inflammation, and promoting tissue regeneration, outperforming conventional dressings. This bioinspired hybrid system demonstrates strong translational potential for precision and multifunctional wound care by uniting adhesion, therapy, and dynamic sensing in one device.