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Related Experiment Videos

Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.

G W Viol, J A Minielly, T Bistricki

    Archives of Pathology & Laboratory Medicine
    |December 1, 1977
    PubMed
    Summary

    Gold therapy for rheumatoid arthritis can cause self-limiting proteinuria. Researchers found immune complexes in the kidneys, suggesting antibodies to tubular antigens, not gold itself, may cause this side effect.

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    Area of Science:

    • Nephrology
    • Rheumatology
    • Immunology

    Background:

    • Gold compounds have been used to treat rheumatoid arthritis.
    • Proteinuria is a potential adverse effect of gold therapy.

    Observation:

    • Three patients undergoing gold therapy for rheumatoid arthritis developed proteinuria.
    • Renal biopsy revealed membranous glomerulopathy with epimembranous deposits.
    • Immunofluorescence showed IgG and C3 deposits in glomerular basement membranes.

    Findings:

    • X-ray fluorescence spectroscopy detected gold within proximal convoluted tubular cells.
    • Gold was not identified in glomerular subepithelial deposits.
    • The renal lesion is consistent with an immune-complex glomerulopathy.

    Implications:

    • Gold itself is unlikely to be the antigen or hapten in the glomerular deposits.
    • The study hypothesizes that gold therapy may induce antibodies against tubular epithelial antigens.
    • This immune response could be the causative factor for gold-associated renal disease in rheumatoid arthritis patients.

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