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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Disorders of the Female Reproductive System01:24

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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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Panic Disorder01:27

Panic Disorder

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Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
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Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

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The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
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Related Experiment Video

Updated: Jan 11, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

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Obsessive-compulsive disorder and menopause: a scoping review.

Carmela Melina Albanese1, Gabriella Antaya2, Jennifer L Gordon3

  • 1Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

Menopause (New York, N.Y.)
|November 17, 2025
PubMed
Summary

Menopause may trigger new obsessive-compulsive disorder (OCD) symptoms or alter existing ones in some individuals. Further research is needed, but monitoring midlife women with OCD is recommended.

Keywords:
Compulsive behaviorMenopauseObsessive behaviorObsessive-compulsive disorder

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Area of Science:

  • Psychiatry and Neuroscience
  • Women's Health
  • Reproductive Endocrinology

Background:

  • Obsessive-compulsive disorder (OCD) is a mental health condition characterized by intrusive thoughts and compulsive behaviors.
  • Female-born individuals have a higher prevalence of OCD, with reproductive events like menarche and postpartum periods linked to symptom severity.

Purpose of the Study:

  • To conduct a scoping review of existing literature on the impact of menopause on the onset and symptoms of obsessive-compulsive disorder.
  • To identify research gaps and inform clinical monitoring strategies for midlife individuals with OCD.

Main Methods:

  • A comprehensive scoping review was performed adhering to PRISMA extension guidelines for scoping reviews.
  • Searches were conducted across four major databases (MEDLINE, Embase, PsycInfo, CINAHL) up to April 15, 2025.
  • Included studies examined the association between menopause and new-onset or altered obsessive-compulsive symptoms.

Main Results:

  • Eight quantitative, cross-sectional studies utilizing self-reported retrospective data were included.
  • 4.6% of participants reported new-onset OCD symptoms coinciding with menopause onset.
  • 27.2% reported symptom exacerbation, while 11.3% reported symptom improvement during menopause.

Conclusions:

  • Current cross-sectional evidence suggests menopause may influence OCD onset and symptom severity in a subset of individuals.
  • Longitudinal studies are essential to prospectively validate these findings across menopausal transition phases.
  • Enhanced symptom monitoring for midlife female-born individuals with OCD is clinically indicated.