Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brainstem: Control Centers of Medulla01:21

Brainstem: Control Centers of Medulla

3.6K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SE-DBIRNet: Squeeze-and-Excitation Driven Dual-Path Residual Network for Mango Shelf-Life Stages Classification.

Foods (Basel, Switzerland)·2026
Same author

4-Octyl Itaconate Promotes Diabetic Wound Healing by Enhancing Pro-Resolving Macrophages via the Efferocytosis-MCT1-Lactate-GPR132 Pathway and Macrophage-Independent Synergistic Effects (Diabetes Metab J 2026;50:707-23).

Diabetes & metabolism journal·2026
Same author

"Immune senescence and dormant tumor cells: reconceptualizing breast cancer recurrence as an affliction of aging and chronic inflammation".

Annals of medicine and surgery (2012)·2026
Same author

Multiple Carboxylase Deficiency in an Infant Presenting With Severe Metabolic Acidosis and Sepsis-Like Features: A Case Report and Literature Review.

Clinical case reports·2026
Same author

Coronary Artery Calcium Scoring for Risk Reclassification and Prediction of Hard Cardiovascular Events in Asymptomatic Adults at Low-to-Intermediate Cardiovascular Risk: A Systematic Review.

Cureus·2026
Same author

Deciphering molecular inputs to CRH neurons from POMC neurons.

Fundamental research·2026

Related Experiment Video

Updated: Jan 11, 2026

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions
03:42

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions

Published on: August 1, 2025

1.1K

Comprehensive Single-Cell Transcriptomic Atlas of the Mouse Pons and Medulla.

Muhammad Junaid1,2,3, Eun Jeong Lee4,5,6, Su Bin Lim7,8,9

  • 1Department of Biochemistry & Molecular Biology, Ajou University School of Medicine, Suwon, 16499, South Korea.

Scientific Data
|November 17, 2025
PubMed
Summary

This study maps the cellular landscape of the mouse pons and medulla, revealing 45 distinct cell types. This brainstem atlas provides a foundational resource for understanding neural and gut-brain communication.

More Related Videos

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells
08:30

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

13.9K
Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing
10:44

Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing

Published on: March 23, 2022

4.8K

Related Experiment Videos

Last Updated: Jan 11, 2026

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions
03:42

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions

Published on: August 1, 2025

1.1K
Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells
08:30

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Published on: January 7, 2020

13.9K
Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing
10:44

Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing

Published on: March 23, 2022

4.8K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Genomics

Background:

  • The pons and medulla, crucial hindbrain regions in the brainstem, govern complex behaviors like motor control and autonomic regulation.
  • Understanding the cellular diversity within these regions is vital for deciphering their roles in neural projections and gut-to-brain communication.

Purpose of the Study:

  • To construct a comprehensive single-cell atlas of the mouse pons and medulla.
  • To identify and characterize the diverse cell types, including neuronal and non-neuronal populations, within these brainstem regions.

Main Methods:

  • Integration of eight single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) datasets from mouse brains.
  • Development of a rigorous metadata standardization and annotation pipeline.
  • Construction of a large-scale single-cell atlas comprising 318,522 cells.

Main Results:

  • Identification of 45 distinct cell types within the pons and medulla, showcasing significant subtype-specific variability.
  • Observation of high diversity among neuronal populations.
  • Characterization of non-neuronal cells, predominantly glial and vascular cells, with unique transcriptional profiles.

Conclusions:

  • The developed single-cell atlas represents a foundational resource for exploring cellular diversity in the pons and medulla.
  • This atlas enables comparative analyses and future research into region-specific functions and gut-brain axis mechanisms.