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ML-Driven optimization of two-phase microfluidic cooling using acoustofluidic bubble actuation and nanoarray-coated
Seyed Hamed Godasiaei1, Pouyan Talebizadehsardari2,3, Amir Keshmiri4
1School of Chemical Engineering and Technology, Xi'an Jiaotong University, Suzhou, PR, China. hamedgoodasiay@gmail.com.
Scientific Reports
|November 17, 2025
Summary
This study introduces an advanced microfluidic cooling system using ultrasound-activated bubbles and nano-coated pins. Machine learning models optimized performance, with Long Short-Term Memory (LSTM) showing superior heat transfer predictions.
Area of Science:
- Microfluidics
- Thermal Management
- Nanotechnology
Background:
- Conventional passive cooling methods face limitations in heat dissipation for high-power electronics.
- Effective two-phase microfluidic cooling requires precise control over boiling dynamics and surface interactions.
Purpose of the Study:
- To develop and optimize a novel two-phase microfluidic cooling strategy.
- To investigate the impact of acoustofluidic bubble activation and nanoarray-coated micropins on thermal performance.
- To utilize machine learning for performance prediction and optimization.
Main Methods:
- Integration of acoustofluidic bubble activation with nanoarray-coated micropin structures.
- Application of deep neural networks (DNN), Long Short-Term Memory (LSTM), and statistical correlation (Spearman, Kendall) for data analysis.
- Utilizing SHAP (DeepSHAP) and partial dependence plots (PDP) for model interpretability.
Main Results:
- The LSTM model demonstrated superior prediction accuracy (lower MAE, SMAPE, RMSE) compared to the DNN.
- Initial temperature and chipset material were identified as key factors influencing the heat transfer coefficient (HTC).
- Acoustofluidic excitation was the primary positive contributor to thermal performance.
Conclusions:
- The proposed microfluidic cooling strategy significantly enhances heat transfer.
- Machine learning, particularly LSTM, provides accurate performance prediction and aids in understanding influential parameters.
- This integrated approach offers a promising solution for advanced thermal management challenges.

