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A Dual-stage Deep Learning Framework for Breast Ultrasound Image Segmentation and Classification
Pierangela Bruno1, Megan Macrì2, Carmine Dodaro2
1Department of Mathematics and Computer Science, University of Calabria, Rende, 87036, CS, Italy. pierangela.bruno@unical.it.
Journal of Medical Systems
|November 17, 2025
Summary
Deep learning models can segment and classify breast masses in ultrasound images, improving early breast cancer detection. This AI approach enhances diagnostic accuracy for malignant versus benign tumors.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Oncology
Background:
- Breast cancer is a leading cause of death among women, making early detection critical.
- Deep Learning (DL) shows promise in enhancing medical image analysis for diagnostics.
- Ultrasound imaging is a key tool for breast mass evaluation.
Purpose of the Study:
- To apply Deep Learning techniques for segmenting and classifying breast masses in ultrasound images.
- To develop a dual-stage pipeline for improved breast cancer diagnosis.
- To evaluate the performance of different DL architectures for this task.
Main Methods:
- A modular, dual-stage DL pipeline was proposed: segmentation followed by classification.
- The pipeline flexibly integrates various backbone architectures (e.g., ResNet34, MobileNetV3-Small, EfficientNet-B0).
- An ablation study was performed to optimize model parameters.
Main Results:
- DeepLabV3+ with ResNet34 achieved the most accurate segmentation of suspicious regions.
- Lightweight classifiers MobileNetV3-Small and EfficientNet-B0 demonstrated superior classification performance.
- The approach showed promising improvements in diagnostic accuracy on two breast ultrasound datasets.
Conclusions:
- The proposed DL pipeline effectively segments and classifies breast masses using ultrasound images.
- The method has the potential to significantly enhance early breast cancer detection and diagnostic accuracy.
- Flexible integration of DL architectures allows for task-specific optimization.

