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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

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Diffusion-T2 correlated spectroscopy imaging to explore possible placental composition changes over gestation.

Xilong Liu¹, Chantao Huang², Sijin Chen^3,4

¹Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong, 510515, China. xilongl@sina.com.

BMC Medical Imaging

|November 18, 2025

Summary

Diffusion-T2 correlated spectroscopy imaging (DT2SI) reveals placental composition changes during pregnancy. This noninvasive MRI technique shows specific compartment volume changes correlating with gestational age, aiding in placental function assessment.

Keywords:

Diffusion MRI Maternal-fetal medicine Placenta Pregnancy T2 relaxometry

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Area of Science:

Biomedical Imaging
Magnetic Resonance Imaging
Medical Physics

Background:

The placenta is crucial for fetal development, but evaluating its function noninvasively during pregnancy remains challenging.
Diffusion-T2 correlated spectroscopy imaging (DT2SI) offers in-vivo compositional analysis of organs.
This study explores DT2SI for assessing placental composition changes throughout gestation.

Purpose of the Study:

To investigate the utility of DT2SI in characterizing placental composition.
To correlate placental compositional changes with gestational age in healthy pregnancies.

Main Methods:

Forty healthy pregnancies underwent 3.0T MRI with DT2SI between 23.1-36.0 weeks of gestational age.
DT2SI data were analyzed to quantify volume fractions (Vm) of 9 distinct placental compartments.
Pearson correlation assessed the relationship between compartment Vm and gestational age.

Main Results:

DT2SI successfully characterized placental composition, with 4-5 spectral peaks observed.
Significant correlations were found between gestational age and compartment volumes: V_A1 increased (r=0.633), while V_A2 (r=-0.465) and V_A3 (r=-0.653) decreased.
Compartments V_B1 (r=0.358) and V_C1 (r=0.411) showed slight to moderate increases with gestational age.

Conclusions:

DT2SI provides comprehensive insights into placental compositional evolution during pregnancy.
The technique demonstrates significant value for noninvasively assessing placental function.
DT2SI holds promise for monitoring pregnancy progression and detecting potential complications.