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Is a shortened postoperative albendazole duration after curative surgery for alveolar echinococcosis possible?
Paul Calame1,2, Carine Richou3,4, Oleg Blagosklonov3,5
1Department of Radiology, University Marie and Louis Pasteur and University Hospital Besançon, 25030, Besançon, France. p1calame@chu-besancon.fr.
Abstract:
In a prospective study of 15 patients with liver alveolar echinococcosis who underwent curative surgery, a strategy to reduce the recommended 2-year postoperative albendazole (ABZ) regimen was evaluated. Guided by negative positron emission tomography computed tomography (PET-CT) and magnetic resonance imaging (MRI) results at 1 year, ABZ was safely discontinued earlier (median 14 months) in 10 patients, with no recurrence observed during the mean 47 months of follow-up, indicating that postoperative ABZ may be safely shortened with careful imaging follow-up. Interestingly, a retrospective analysis of the rEm18AB antibody index showed that a negative index was not required for ABZ withdrawal, although a declining trend supported the decision.
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