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Virucidal Effects of Contact Lens Disinfectants Against Enveloped and Nonenveloped Pathogenic Viruses Causing

Weiyin Hu1, Hiroshi Shimoda, Daisuke Hayasaka

  • 1Laboratory of Veterinary Microbiology (W.H., H.S., D.H.), Department of Veterinary Medicine, Joint Graduate School of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan; Laboratory of Veterinary Microbiology (H.S., D.H.), Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan; and Division of Pathogenic Microorganism (H.S., D.H.), Research Center for Thermotolerant Microbial Resources, Yamaguchi University, Yamaguchi, Japan.

Eye & Contact Lens
|November 18, 2025
PubMed
Abstract

Insights

Sodium hypochlorite and hydrogen peroxide contact lens disinfectants effectively kill enveloped SARS-CoV-2 and nonenveloped Human Adenovirus. Other disinfectants showed limited efficacy against Human Adenovirus, highlighting the importance of proper contact lens care.

Area of Science:

  • Ophthalmology
  • Virology
  • Microbiology

Background:

  • Contact lens (CL) contamination poses a risk for viral keratoconjunctivitis transmission.
  • Human adenovirus (HAdV-D) and SARS-CoV-2 can cause ocular infections due to inadequate disinfection and viral stability in disinfectants.

Purpose of the Study:

  • To evaluate the antiviral efficacy of commercial CL disinfectants against HAdV-D and SARS-CoV-2.
  • To identify effective disinfectants for preventing viral transmission via contact lenses.

Main Methods:

  • Cytotoxicity of CL disinfectants was assessed in cell lines.
  • Viruses were incubated with disinfectants following manufacturer protocols.
  • Infectious viral titers were determined post-incubation and compared to controls.

Main Results:

  • Sodium hypochlorite and hydrogen peroxide disinfectants inactivated both SARS-CoV-2 and HAdV-D56.
  • Salicylic acid and some PHMB-based disinfectants inactivated SARS-CoV-2 but not HAdV-D56.
  • Other disinfectants (PHMB, ɛ-polylysine, PQ-1, alexidine hydrochloride) showed limited efficacy against both viruses.

Conclusions:

  • Sodium hypochlorite and hydrogen peroxide-based CL disinfectants demonstrate potent virucidal activity against enveloped and nonenveloped viruses.
  • Human adenovirus is a significant cause of conjunctivitis.
  • Daily disinfection of contact lenses using manufacturer protocols is recommended.
Keywords:
Contact lens disinfectantsHuman adenovirusInactivationOcular infectionSARS-CoV-2

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