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Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...

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Updated: Jan 11, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

[Risk factors for white matter damage in preterm infants with necrotizing enterocolitis].

Xin Xu¹, Si-Rui Wang¹, Peng Zhang

¹Department of Neonatology, Children's Hospital of Fudan University, Shanghai 201102, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics

|November 18, 2025

Summary

Necrotizing enterocolitis (NEC) in preterm infants is linked to white matter damage (WMD). Surgical treatment, longer hospital stays, and abnormal EEG findings increase WMD risk, guiding early intervention for better neurological outcomes.

Area of Science:

Neonatal Neurology
Pediatric Gastroenterology
Neuroimaging in Neonates

Keywords:

Magnetic resonance imaging Necrotizing enterocolitis Preterm infant Risk factor White matter damage

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