[Efficacy and safety of inhaled salbutamol sulfate combined with beclomethasone dipropionate in children with bronchial asthma: a randomized controlled study]
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View abstract on PubMed
Summary
This summary is machine-generated.Inhaled beclomethasone dipropionate combined with salbutamol sulfate effectively treats pediatric bronchial asthma by reducing symptoms and improving immune balance. This combination therapy shows good safety and efficacy in children.
Area Of Science
- Pediatric Pulmonology
- Respiratory Medicine
- Clinical Immunology
Background
- Pediatric bronchial asthma remains a significant respiratory challenge.
- Effective management strategies are crucial for improving quality of life and reducing exacerbations.
Purpose Of The Study
- To evaluate the efficacy and safety of combining inhaled salbutamol sulfate with beclomethasone dipropionate in pediatric bronchial asthma.
- To assess the impact on symptom relief, asthma control, immune markers, and adverse events.
Main Methods
- A randomized controlled trial involving 106 children with bronchial asthma.
- Comparison between a control group (salbutamol sulfate) and a treatment group (salbutamol sulfate + beclomethasone dipropionate).
- Assessment of symptom relief time, asthma control, hematologic indices, IL-4, IFN-γ, infection, and adverse events.
Main Results
- The treatment group experienced significantly shorter symptom relief and resolution times.
- Improved asthma control scores, elevated IFN-γ levels, and a better lymphocyte-to-monocyte ratio were observed in the treatment group.
- The treatment group showed reduced neutrophil-to-lymphocyte ratio, eosinophil-to-lymphocyte ratio, IL-4 levels, lower infection incidence, and fewer adverse events.
Conclusions
- Combined inhaled salbutamol sulfate and beclomethasone dipropionate significantly enhance clinical efficacy in pediatric bronchial asthma.
- This combination therapy promotes T helper 1/T helper 2 immune balance and optimizes hematologic indices.
- The treatment regimen demonstrates a favorable safety profile for managing pediatric bronchial asthma.
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