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[The microbiota-gut-brain axis in childhood attention-deficit/hyperactivity disorder: mechanisms and therapeutic

Ying-Lun Yuan1, Yong-Mei Lan1, Lin-Mei Guo

  • 1Department of Pediatrics, 940th Hospital of Joint Service Support Force of the People's Liberation Army, Lanzhou 730050, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|November 18, 2025
PubMed

Insights

Attention-deficit/hyperactivity disorder (ADHD) in children is linked to gut bacteria imbalances. Research explores the gut-brain axis for new ADHD treatments targeting gut microbiota.

Area of Science:

  • Neuroscience
  • Microbiology
  • Pediatrics

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children.
  • Emerging research indicates a connection between ADHD and gut microbiota dysbiosis.
  • The microbiota-gut-brain axis is a novel area of focus for understanding childhood ADHD.

Purpose of the Study:

  • To systematically review the association between gut dysbiosis and childhood ADHD.
  • To analyze the mechanisms of the microbiota-gut-brain axis in regulating gut-brain communication.
  • To highlight microbiota-targeted strategies and therapeutic prospects for ADHD.

Main Methods:

  • Systematic literature review.
  • Analysis of bidirectional gut-brain communication pathways.
  • Evaluation of microbiota-targeted interventions.

Main Results:

  • Gut dysbiosis is significantly associated with ADHD in children.
  • The microbiota-gut-brain axis influences ADHD through various pathways.
  • Microbiota-targeted strategies show promise for symptom improvement.

Conclusions:

  • The gut microbiota plays a crucial role in childhood ADHD.
  • Targeting the gut microbiota offers potential for novel therapeutic interventions.
  • Further research into the microbiota-gut-brain axis may lead to new avenues for early ADHD treatment.

Keywords:
Attention-deficit/hyperactivity disorderChildGut microbiotaMicrobiota-gut-brain axisMicrobiota-targeted therapy

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