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Beyond Selective Serotonin Reuptake Inhibitor (SSRIs): Exploring Hormonal Therapy for Mood Disorders in Perimenopause

Raja Mogallapu1, Rebecca Sarich1, Ankit Chalia1

  • 1Behavioral Health, West Virginia University School of Medicine, Martinsburg, USA.

Cureus
|November 18, 2025
PubMed
Summary

Hormone replacement therapy (HRT) with estradiol can effectively manage mood disorders during perimenopause and postmenopause. This approach, combined with psychotropic care, improved mood instability and depression in two women.

Keywords:
estradiolperimenopause depression hormone replacement therapy (hrt)phq-9progesteronevasomotor symptoms

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