Despite lower haemoglobin A1c with second-generation automated insulin delivery systems, mental burden remains high for all adults with type 1 diabetes: A BETTER registry analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Second-generation automated insulin delivery systems (AIDs) improve HbA1c and satisfaction in type 1 diabetes. However, mental burden and sleep issues persist across all advanced diabetes technology groups.
Area Of Science
- Endocrinology
- Metabolic Diseases
- Medical Technology
Background
- Type 1 diabetes management requires continuous glucose monitoring and insulin delivery.
- Automated insulin delivery (AID) systems represent advancements in diabetes technology.
- Second-generation AIDs offer enhanced features compared to earlier systems.
Purpose Of The Study
- To compare glucose management and patient-reported outcomes (PROs/PREs) of second-generation AIDs against other treatment modalities in adults with type 1 diabetes.
- To evaluate treatment satisfaction, hypoglycemia fear, diabetes distress, and sleep quality across different diabetes management strategies.
Main Methods
- Cross-sectional analysis of the Canadian BETTER type 1 diabetes registry.
- Categorization of 1731 adult participants into five treatment groups: second-generation AIDs, first-generation AIDs, CGM+pump, CGM+MDI, and non-CGM.
- Generalized linear models used to compare outcomes, with statistical significance set at p < 0.05.
Main Results
- Second-generation AID users showed the highest proportion of achieving HbA1c ≤ 7% (58.1%) compared to other groups (p < 0.001).
- Users of second-generation AIDs reported higher treatment satisfaction.
- No significant differences in other PROs/PREs were observed between second-generation AIDs and other groups.
- High rates of diabetes distress (55%) and poor sleep quality (63%) were prevalent across all treatment modalities.
Conclusions
- Second-generation AIDs are associated with improved glycemic control (lower HbA1c) and higher treatment satisfaction in real-world type 1 diabetes management.
- Despite advanced technology and optimal glucose levels, significant mental burden and sleep disturbances persist.
- Further research is needed to address the ongoing psychological and well-being challenges faced by individuals with type 1 diabetes, even with advanced AID systems.
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