Related Experiment Video
Updated: Jan 11, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
Neuropsychiatric profile of Alzheimer's disease with hallucinations
Antonina Luca1, Maria Luca2, Alessandro Serretti1,3
1Department of Medicine and surgery, Kore University of Enna, Italy.
Abstract:
The aim of the study was to estimate the prevalence of hallucinations in patients with AD and to assess its associated clinic-demographic and neuropsychiatric profile. Three hundred and eighty-one patients collected within the National Institute of Mental Health Genetics Initiative were included. Characteristics of hallucinators and non-hallucinators were compared by logistic regression. One hundred sixty-nine (44.4%) patients were hallucinators. Hallucinators presented a more severe AD than non-hallucinators with a lower MMSE (10.6 ± 8.9 versus 14.6 ± 8.9; OR 0.9; 95%CI 0.92-0.97; p-value < 0.001) and a higher CDRS (2.7 ± 1.0 versus 2.4 ± 1.1; OR 1.2; 95%CI 1.01-1.44; p-value 0.035). Hallucinators presented a more severe neuropsychological profile, characterised by apathy, verbal and physical aggressivity, and wandering. Hallucinations may represent a clinically useful tool for identifying patients who may require more intensive interventions.
More Related Videos
Related Concept Videos
Positive Symptoms Schizophrenia: Hallucinations and Delusions
Hallucinations
Hallucinations in...
Hallucinogens and Psychedelics
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Alzheimer's Disease: Treatment
CNS Stimulants: Psychedelic Agents

