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Updated: Jan 11, 2026
08:01
A Web Tool for Generating High Quality Machine-readable Biological Pathways
Published on: February 8, 2017
18.4K
The Reactome Knowledgebase 2026
Eliot Ragueneau1, Chuqiao Gong1, Pierre Sinquin1
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Nucleic Acids Research
|November 18, 2025
Summary
Reactome is a comprehensive human biology knowledgebase. Its updated interface and tools enhance data access, visualization, and analysis for biological research.
Area of Science:
- Molecular Biology
- Bioinformatics
- Systems Biology
Background:
- Reactome provides expert-curated data on human molecular pathways.
- It covers normal physiology and disease mechanisms, including genetic and drug impacts.
- Data integrity is maintained through automated monitoring of publications.
Purpose of the Study:
- To describe the latest updates and features of the Reactome Knowledgebase.
- To highlight enhancements in user interface, visualization, and analysis tools.
- To emphasize Reactome's commitment to FAIR data principles and its role as a trusted resource.
Main Methods:
- Redesigned Angular-based interface with improved accessibility and modular architecture.
- Introduced new visualization tools: ReacFoam, enhanced pathway diagrams, and entity level views (ELVs).
- Developed new analysis tools for multi-omics integration and customizable visualizations, including a chatbot and icon library.
Main Results:
- Launched a redesigned, user-friendly interface with advanced visualization capabilities.
- Integrated new analysis tools supporting multi-omics data and natural language interaction.
- Achieved CoreTrustSeal certification and designation as a Global Core Biodata and ELIXIR resource.
Conclusions:
- The updated Reactome Knowledgebase offers enhanced accessibility and powerful tools for molecular biology research.
- New features facilitate multi-omics integration, intuitive navigation, and comparative analysis of biological states.
- Reactome's commitment to data integrity, FAIR principles, and community engagement solidifies its position as a vital global resource.
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