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Related Experiment Video

Updated: Jan 11, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

The Reactome Knowledgebase 2026.

Eliot Ragueneau¹, Chuqiao Gong¹, Pierre Sinquin¹

¹European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.

Nucleic Acids Research

|November 18, 2025

Summary

This summary is machine-generated.

Reactome is a comprehensive human biology knowledgebase. Its updated interface and tools enhance data access, visualization, and analysis for biological research.

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Area of Science:

Molecular Biology
Bioinformatics
Systems Biology

Background:

Reactome provides expert-curated data on human molecular pathways.
It covers normal physiology and disease mechanisms, including genetic and drug impacts.
Data integrity is maintained through automated monitoring of publications.

Purpose of the Study:

To describe the latest updates and features of the Reactome Knowledgebase.
To highlight enhancements in user interface, visualization, and analysis tools.
To emphasize Reactome's commitment to FAIR data principles and its role as a trusted resource.

Main Methods:

Redesigned Angular-based interface with improved accessibility and modular architecture.
Introduced new visualization tools: ReacFoam, enhanced pathway diagrams, and entity level views (ELVs).
Developed new analysis tools for multi-omics integration and customizable visualizations, including a chatbot and icon library.

Main Results:

Launched a redesigned, user-friendly interface with advanced visualization capabilities.
Integrated new analysis tools supporting multi-omics data and natural language interaction.
Achieved CoreTrustSeal certification and designation as a Global Core Biodata and ELIXIR resource.

Conclusions:

The updated Reactome Knowledgebase offers enhanced accessibility and powerful tools for molecular biology research.
New features facilitate multi-omics integration, intuitive navigation, and comparative analysis of biological states.
Reactome's commitment to data integrity, FAIR principles, and community engagement solidifies its position as a vital global resource.