Keratoprosthesis Indications, Outcomes, and Future Directions

Area of Science:

• Ophthalmology
• Biomaterials Science
• Surgical Innovation

Background:

• Corneal transplantation faces limitations for certain patient groups.
• Keratoprosthesis (KPro) provides a solution for complex corneal diseases.
• The Boston KPro is a widely used artificial cornea device.

Purpose of the Study:

• To review the development, design, and surgical aspects of keratoprosthesis (KPro).
• To analyze complications, outcomes, and challenges associated with the Boston KPro.
• To identify future research directions for KPro technology.

Main Methods:

• A narrative literature review was performed.
• Examined the evolution and current technologies of artificial corneas.
• Focused specifically on the Boston Keratoprosthesis.

Main Results:

• Identified areas for Boston KPro improvement: titanium backplates, graft adhesion, and donor graft preparation.
• Highlighted challenges in glaucoma monitoring due to unreliable intraocular pressure measurements.
• Explored adjunctive strategies, cost-containment, accessibility, and new KPro designs.

Conclusions:

• Keratoprosthesis is a viable option for patients ineligible for traditional corneal transplants.
• Continued research in surgical techniques, materials, prophylaxis, and design is crucial.
• Enhancing patient outcomes, minimizing complications, and increasing global access to KPro are key goals.