Nanoclay-Interface-Mediating Charge Redistribution for Effective Wound Healing

Reconciling rapid hemostasis with sustained antimicrobial activity remains a major challenge for wound therapeutics. We demonstrate a nanoclay-interface-mediated charge redistribution strategy by hybridization of an aggregation-induced-emission luminogen (AIEgen), TTPy, with montmorillonite (MMT). Molecular dynamics and time-of-flight secondary ion mass spectrometry (ToF-SIMS) reveal Ca²⁺ enrichment via cation-π/electrostatic interactions, while density functional theory shows that TTPy downshifts the O 2p band, weakening Ca-O coordination and enhancing Ca²⁺ bioavailability. This interfacial modulation accelerates coagulation cascades, yielding a 90 s clotting time, and simultaneously establishes a photostable bactericidal surface that eradicates Staphylococcus aureus through adhesion and light-triggered reactive oxygen species. In vivo, MMT-TTPy synergizes fibrin formation and bacterial clearance, achieving 84.8% wound closure in 10 days. These results identify interfacial charge redistribution as the molecular origin of dual hemostatic-antimicrobial activity.