Related Experiment Video
Updated: May 11, 2026

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells
Published on: December 22, 2010
Green Synthesis of a Hyaluronan-Based Multimeric A9 Peptide System: Polysaccharide-A9 Conjugate with Enhanced HER2
Valentina Verdoliva1, Alfio Pulvirenti2, Giuseppe Digilio3
1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, National Research Council (CNR), Institute of Crystallography, Via Vivaldi, 43, 81100 Caserta, Italy.
Abstract:
A solid-state strategy for conjugating the peptide sequence A9 to hyaluronic acid (HA) has been developed via mechanosynthesis promoted by microwave radiation. The method employs a silica-supported nucleophilic catalyst (DMAP) to activate the carboxylic groups of the polysaccharide, enabling efficient conjugation. These conditions minimize waste generation, enhancing environmental sustainability and operator safety while ensuring a high yield of the final HA-A9 conjugate. The multicopy HA-A9 system exhibits enhanced affinity toward a synthetic HER2 receptor model. Furthermore, the HA-A9 conjugate demonstrates the ability to self-assemble into micellar aggregates and form viscous materials enriched with β-sheet peptide structures. These supramolecular assemblies highlight the potential of conjugates for biomedical applications.
Related Concept Videos
Recombinant DNA
Sugars as Energy Storage Molecules
Sugars as Energy Storage Molecules
Production of Pharmaceuticals

