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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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The Association of Faecal Calprotectin Measurements With Endo-Histological Remission in Ulcerative Colitis: A Pooled Analysis.

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Related Experiment Video

Updated: Jan 11, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

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Postoperative Ileum Transcriptomics Implicate Sex-Biased Mechanisms in Crohn's Disease Recurrence.

Kyle Gettler1, Sini Nagpal2, Savannah Washburn2

  • 1Department of Pathology, Molecular, and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Gastroenterology
|November 18, 2025
PubMed
Summary

Crohn's disease recurrence involves distinct molecular pathways, with nuclear hormone signaling and sex-specific gene expression changes in the neoterminal ileum. These findings offer new therapeutic targets beyond anti-inflammatory blockade.

Keywords:
Crohn’s DiseaseGenomicsInflammatory Bowel DiseaseRNA-SeqSingle Cell

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Genetics

Background:

  • Crohn's disease (CD) frequently recurs after surgery, necessitating surveillance.
  • Neoterminal ileum gene expression at surveillance colonoscopies reveals disease recurrence pathways.
  • Understanding these molecular mechanisms is crucial for managing postoperative CD.

Purpose of the Study:

  • To investigate molecular mechanisms underlying recurrent Crohn's disease in the neoterminal ileum.
  • To identify specific gene expression patterns and pathways associated with disease recurrence.
  • To evaluate the role of sex and nuclear hormone pathways in recurrence.

Main Methods:

  • Transcriptome sequencing of 339 neoterminal ileal biopsies from 267 patients.
  • Differential gene and transcript usage analysis.
  • Expression quantitative trait loci (eQTL) analysis and serial sampling in 70 patients.

Main Results:

  • Significant alterations in gene expression were observed in recurrent vs. non-recurrent CD.
  • Greater dynamic ranges of gene expression were noted in male compared to female patients.
  • Activation of nuclear hormone receptor pathways (estrogen, dihydrotestosterone) and inhibition of progesterone were identified, alongside lipid metabolism and extracellular matrix pathway involvement.

Conclusions:

  • Recurrent Crohn's disease in the neoterminal ileum exhibits sex-specific gene expression patterns.
  • Nuclear hormone pathways represent novel therapeutic targets for Crohn's disease recurrence.
  • Identified pathways differ from those driving initial disease susceptibility, offering new insights into management.