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Updated: Jan 11, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
Published on: December 15, 2014
The apparent diffusion coefficient as a potential radiological biomarker of malignant transformation in
Sonia De Francesco1, Paolo Galluzzi2, Tommaso Padula3
1Department of Medicine, Surgery and Neuroscience, Unit of Ophthalmology Ocular Oncology - Retinoblastoma Referral Center, Azienda Ospedaliera Universitaria Senese, Viale Bracci 1, 53100, Siena, Italy. defrancesco75@libero.it.
Abstract:
We report a unique case of malignant transformation in a retinocytoma monitored using magnetic resonance imaging (MRI). This case is notable for a distinct drop in apparent diffusion coefficient (ADC) values that correlated with clinical transformation to retinoblastoma. This is the first report to highlight a change in ADC as a radiological marker of malignant conversion in retinocytoma. This finding suggests the potential role of ADC in prognostic assessment and risk stratification for patients with retinocytoma.

