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Epidemiology of Rotavirus Gastroenteritis in Children Under Five in Maharashtra, India: A Multicenter Surveillance

Madhuri Engade1, Mohammad Haseeb2, Shaikh Yahiya Ali1

  • 1Department of Pediatrics, Mahatma Gandhi Mission (MGM) Medical College and Hospital, MGM Institute of Health Sciences, Ch Sambhajinagar (Aurangabad), 431003, Maharashtra, India.

Indian Journal of Pediatrics
|November 18, 2025
PubMed

Insights

Rotavirus gastroenteritis (RVGE) significantly impacts children under five in Maharashtra, India. Surveillance revealed seasonal patterns and common G3P[8] and G2P[4] genotypes, emphasizing the need for targeted vaccination strategies.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Public Health Surveillance

Background:

  • Rotavirus gastroenteritis (RVGE) is a leading cause of severe illness and death in young children globally, particularly in India.
  • Understanding the epidemiology of RVGE is crucial for developing effective control and prevention strategies.

Purpose of the Study:

  • To investigate the prevalence, seasonality, age distribution, clinical features, and circulating rotavirus genotypes in children under five with acute gastroenteritis in Maharashtra, India.
  • To inform public health interventions and vaccination programs.

Main Methods:

  • A descriptive, multicenter surveillance study was conducted in Maharashtra from December 2020 to December 2023.
  • Stool samples from children aged 0-59 months with acute gastroenteritis were tested for rotavirus using ELISA, and positive samples underwent genotyping.
  • Demographic and clinical data were collected and analyzed using descriptive statistics.

Main Results:

  • Rotavirus was detected in 32.7% of 534 stool samples. Rotavirus positivity rates were similar between vaccinated (32.6%) and unvaccinated (32.9%) children.
  • RVGE incidence peaked in 2022 and was higher during cooler months and in children aged 12-23 months.
  • Rotavirus-positive children exhibited higher rates of vomiting, diarrhea, fever, and severe dehydration. Predominant genotypes were G3P[8] (47.8%) and G2P[4] (19.4%).

Conclusions:

  • Rotavirus remains a significant cause of severe gastroenteritis in young children in Maharashtra, exhibiting distinct seasonal and age-related patterns.
  • The findings underscore the necessity of continuous surveillance and adaptive vaccination strategies to mitigate the burden of RVGE.
Abstract

Keywords:
DiarrheaGenotype distributionMaharashtraRotavirus gastroenteritis

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