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Honeysuckle-Derived Exosome-Like Nanovesicles Alleviate Cisplatin-Induced Acute Kidney Injury by Anti-Inflammation
Wan-Cheng Gong1,2,3, Jing-Xuan Li3, Xiao-Juan Hu2,3
1College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.
Chinese Journal of Integrative Medicine
|November 18, 2025
Summary
Honeysuckle-derived nanovesicles (HELNVs) show promise in preventing acute kidney injury (AKI) caused by cisplatin. HELNVs reduced kidney damage, inflammation, and oxidative stress in preclinical models.
Area of Science:
- Nanomedicine
- Nephrology
- Biochemistry
Background:
- Cisplatin chemotherapy can cause acute kidney injury (AKI), a serious side effect.
- Current treatments for cisplatin-induced AKI are limited.
Purpose of the Study:
- To investigate the potential of honeysuckle-derived exosome-like nanovesicles (HELNVs) as a renoprotective agent against cisplatin-induced AKI.
Main Methods:
- Assessed HELNVs efficacy in cisplatin-treated HK-2 cells and a cisplatin-induced AKI mouse model.
- Measured reactive oxygen species (ROS), inflammatory markers (IL-1β, IL-6, TNF-α, IL-10), kidney function (serum creatinine, BUN), and HELNVs renal uptake.
Main Results:
- HELNVs significantly reduced ROS, inflammation, and apoptosis in kidney cells.
- In vivo, HELNVs prevented oxidative damage and mitochondrial dysfunction in AKI mice.
- HELNVs treatment markedly reduced serum creatinine and BUN levels, and modulated inflammatory cytokine profiles.
Conclusions:
- HELNVs demonstrate significant renoprotective effects against cisplatin-induced AKI.
- HELNVs represent a promising therapeutic strategy for managing cisplatin-induced kidney damage.
Keywords:
anti-apoptosisantiinflammationcisplatin-induced acute kidney injuryhoneysuckle-derived exosome-like nanovesiclesmitochondrial function protectionMore Related Videos
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