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Bridging mesoscopic and microscopic scales in multiple sclerosis: Post mortem brain block multi-contrast 9.4T MRI and
Dimitrios G Gkotsoulias1, Lukas Schönenberger1, Jochen Leupold2
1Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland; Translational Imaging in Neurology Basel, Department of Biomedical Engineering, Faculty of Medicine, University of Basel, Allschwil, Switzerland; Department of Neurology, University Hospital Basel, Basel, Switzerland.
None:
Combining ex vivo MRI mesoscopic and histopathology microscopic assessments of tissue microstructure forms a key approach in multiple sclerosis (MS) research for elucidating disease pathogenesis. We present a protocol that enables reproducible, scalable, and robust integration of MRI and histology data in MS brains. We describe steps for (1) obtaining high-resolution multi-contrast 9.4T MRI of postmortem brain blocks and (2) the usage of a custom, open-source image processing interface for robust histology-MRI registration and semi-quantitative mapping of myelin density, microglia, and cell count.
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