Clinical Features and Long-Term Outcomes in 109 Pediatric Generalized Pustular Psoriasis
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric-onset generalized pustular psoriasis (PGPP) flares decrease with age but remain common. Earlier onset PGPP is linked to more frequent flares, with biologics now the primary treatment.
Area Of Science
- Dermatology
- Pediatric Immunology
- Clinical Research
Background
- Pediatric-onset generalized pustular psoriasis (PGPP) is a rare, challenging inflammatory condition.
- Characterized by recurrent flares and complex management needs.
Purpose Of The Study
- To review clinical features of PGPP.
- To analyze flare patterns and identify triggers.
- To evaluate current and evolving treatment options.
Main Methods
- Retrospective analysis of 109 PGPP patients (2006-2023).
- Data collection via medical records and telephone surveys.
- Analysis of flare frequency, duration, triggers, and treatment modalities.
Main Results
- Median onset age was 6 years; higher prevalence in males.
- Respiratory infection was the most common trigger.
- Flare frequency and duration decreased with age; earlier onset correlated with higher frequency.
- Conventional therapies (acitretin) were common before 2020; biologics (secukinumab) are now prevalent.
Conclusions
- PGPP flares tend to decrease with age, but recurrence is frequent.
- Early onset PGPP may be associated with increased flare frequency.
- Biologic agents represent the current standard of care for PGPP.
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