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Catch-Up Growth in Syndromic Robin Sequence: A Systematic Review
Sogand Schafer1, Jason Yu2,3, John Mulliken4
1Division of Plastic and Reconstructive Surgery, Department of Surgery, Center for Craniofacial Innovation, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Summary
Mandibular catch-up growth in syndromic Robin sequence (RS) is unclear. Some syndromic RS cases may show spontaneous mandibular growth, potentially reducing surgical intervention needs.
Area of Science:
- Craniofacial Surgery
- Pediatric Genetics
- Otolaryngology
Background:
- Robin sequence (RS) is characterized by micrognathia, glossoptosis, and airway obstruction.
- Syndromic RS comprises approximately 60% of cases, with uncertain mandibular growth patterns.
Purpose of the Study:
- To systematically review the literature for evidence of mandibular catch-up growth in syndromic Robin sequence.
- To assess the potential for conservative management in syndromic RS based on growth patterns.
Main Methods:
- A PRISMA-guided systematic literature review was conducted.
- PubMed database was searched for studies on syndromic RS managed conservatively.
- Included case reports, series, and chart reviews with associated syndromes and sufficient follow-up.
Main Results:
- Thirty-four studies with 202 cases across 20 syndromes were included.
- Stickler syndrome and 22q11.2 deletion syndrome were most common.
- Evidence suggests potential for balanced growth or catch-up growth, but limitations exist.
Conclusions:
- Available literature indicates potential spontaneous mandibular growth in certain syndromic RS groups.
- This may reduce the need for surgical interventions like distraction osteogenesis.
- Further prospective research with standardized measures is required to guide management decisions.
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