Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intrathecal Delivery of Macromolecules to the Spinal Cord Enabled by Laser-Activated Perfluorocarbon Nanodroplets.

ACS nano medicine·2026

Same author

Isolated and combined effects of papillary muscle approximation and mitral annuloplasty in dilated left ventricles.

JRSM cardiovascular disease·2026

Same author

Quad-Channel In Vivo Photoacoustic Multiplexing Using Tunable Gold Nanorods.

ACS nano·2026

Same author

Quantitative photoacoustic tomography of skin vasculature predicts subcutaneous implant exposure.

Journal of biomedical optics·2026

Same author

Protease-Activated Plasmonic Nanosensors for Predictive Ultrasound-Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Double-Emulsion Perfluorocarbon Nanodroplets for Ultrasound and Photoacoustic Image-Guided Drug Delivery and Release.

ACS nano·2025

Search research articles

Related Experiment Video

Updated: Jan 11, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Assessing myocardial stiffness with transient elastography using catheter-compatible miniature actuator.

Samuel M A Morais¹, Andrei B Karpiouk¹, Donald J VanderLaan¹

¹School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

|November 18, 2025

Summary

This study introduces a miniaturized transient elastography (TE) system for measuring heart tissue stiffness via catheters. This technology offers quantitative myocardial elasticity assessment during cardiac procedures.

Keywords:

Heart failure Intracardiac analysis Miniature piezoelectric actuator Myocardial elasticity Shear modulus Shear waves Transient elastography

More Related Videos

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Related Experiment Videos

Last Updated: Jan 11, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

Area of Science:

Biomedical Engineering
Cardiovascular Research
Medical Imaging

Background:

Myocardial elasticity is crucial for understanding cardiovascular diseases like heart failure.
Current methods for assessing myocardial mechanics during catheterization are limited.

Purpose of the Study:

To develop and validate a miniaturized transient elastography (TE) system for measuring myocardial elasticity.
To integrate this TE system into catheter-based cardiac procedures for real-time assessment.

Main Methods:

A miniature piezoelectric actuator generated longitudinal shear waves (LSWs) in phantoms and ex vivo porcine heart tissue.
Ultrasound transducer visualized LSW propagation; spatiotemporal displacement maps analyzed for shear wave speed and modulus.
Results compared with conventional acoustic radiation force-based shear wave elasticity imaging (SWEI).

Main Results:

TE measurements showed strong agreement with SWEI, with no statistically significant differences.
The system demonstrated sensitivity to myocardial tissue anisotropy and distinguished between fresh and preserved tissue.
A noticeable increase in stiffness was detected in fixed heart tissue compared to fresh tissue.

Conclusions:

The miniaturized TE framework is feasible for catheter integration.
This technology can quantitatively assess myocardial elasticity during routine catheterization.
It represents a functional extension to existing clinical workflows for cardiovascular assessment.