[A Case of Urinary Retention Presenting as Oxaliplatin-Induced Acute Peripheral Neuropathy]

The patient was a man in his 70s. He had undergone sigmoid colon resection and D3 dissection 10 years earlier for sigmoid colon cancer and liver metastases. The patient postoperatively received FOLFOX4+bevacizumab(BEV), followed by tegafur/uracil. Increased lymph node metastasis was observed 2 years prior, and treatment with tegafur/gimeracil/oteracil was initiated. However, the tumor continued to grow, and the treatment was switched to CAPOX+BEV. Urinary retention was noted after completing the first oxaliplatin(L-OHP)course. The speed of administration was halved, and a second dose was administered; however, urinary retention occurred again during L-OHP administration, which was therefore discontinued. The treatment was subsequently changed to CAPIRI+BEV, and the urinary retention symptoms resolved. The urinary retention was attributed to acute peripheral neuropathy caused by L-OHP. The absence of urinary retention during the postoperative administration of FOLFOX4+BEV and its onset during the current administration of CAPOX+BEV may have been due to benign prostatic hyperplasia, which developed 5 years prior. Benign prostatic hyperplasia may be a risk factor for urinary retention in patients with acute peripheral neuropathy caused by L-OHP.