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Updated: Jan 11, 2026

Bovine Mammary Gland Biopsy Techniques
Published on: December 23, 2018
[Estimation of standardized doses of intramammary formulations for use in cattle available in Argentina]
Agostina Peña1, Cecilia Camussone1, Facundo Tello1
1Instituto de Investigación de la Cadena Láctea (INTA-CONICET), Estación Experimental Agropecuaria Rafaela, Rafaela, Santa Fe, Argentina.
Abstract:
Standardized doses such as defined daily doses (DDDvet) and defined course doses (DCDvet) are essential to quantify the antimicrobials (AMs) used in veterinary medicine as a prior step for determining strategies for their responsible use. Therefore, the aim of this study was to create a list of the available intramammary formulations for mastitis and drying off in Argentina, and to estimate their DDDvet and DCDvet. DDDvet and DCDvet were determined for 29 mastitis cases and 27 drying formulations. Critically important AM formulations of the highest priority for human health (ceftiofur or cefquinome) were identified. In addition, there were combined formulations with up to four different AMs, including critically important AMs. The results of this study show a high diversity of formulations and concentrations, low availability of mono-drug products, and a high proportion of combinations that include AMs considered essential for human health. These findings highlight the urgent need to standardize dosages in Argentina, prioritize the use of AMs of low medical importance, and promote the prudent and rational use of these drugs, in line with a One Health approach.
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