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The emerging epitranscriptomic modification ac4C regulates plant development and stress adaptation
Jiayu Yao1, Guiyu Xiao1, Xuan Ma2
1State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Agriculture, Guangxi University, Nanning, China.
Nature Plants
|November 18, 2025
Summary
N4-acetylcytidine, an RNA modification, is crucial for plant development and adaptation. This review explores its mechanisms, impact, and potential for improving crops.
Area of Science:
- Molecular Biology
- Plant Science
- Epigenetics
Background:
- N4-acetylcytidine is a conserved RNA modification impacting transcript stability and translation.
- Its role in plant transcriptomes is less understood compared to mammals.
Purpose of the Study:
- To review the prevalence and functional importance of N4-acetylcytidine in plants.
- To discuss its deposition, influence on development and adaptation, and future directions.
Main Methods:
- Literature review of recent advances in transcriptome-wide mapping.
- Functional characterization studies in plant systems.
Main Results:
- N4-acetylcytidine plays a significant role in plant-specific processes.
- It influences plant development and adaptation.
Conclusions:
- Understanding N4-acetylcytidine is key to plant biology.
- Potential applications exist for crop improvement through manipulation of this RNA modification.
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