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Functional polysaccharide-based bioactive delivery systems for urinary and reproductive system therapeutics
Yung-Wei Lin1,2,3, Lekshmi Rethi4,5, Wen-Yu Pan6,7
1International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Drug Delivery and Translational Research
|November 18, 2025
Summary
Advanced polysaccharide delivery systems offer new hope for treating lower genitourinary (GU) organ damage and dysfunction. These innovative regenerative therapies promise improved site-specific delivery and long-term efficacy for enhanced patient outcomes.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Urology
Background:
- Lower genitourinary (GU) organ damage threatens health and fertility, necessitating advanced regenerative treatments.
- Polysaccharide-based delivery systems show promise but face challenges in site-specific delivery, bioactivity, and sustained release.
- Current strategies require optimization for effective long-term therapeutic efficacy.
Purpose of the Study:
- To review recent advancements in polysaccharide-based delivery systems for lower GU regenerative therapies.
- To explore innovative designs, manufacturing technologies, and bioactive loading strategies.
- To highlight applications enhancing clinical outcomes for GU disorders.
Main Methods:
- Review of recent literature on polysaccharide-based delivery systems for GU regeneration.
- Analysis of smart delivery technologies, tailored biomaterials, and bioresponsive platforms.
- Examination of manufacturing technologies and bioactive loading strategies.
Main Results:
- Integration of smart technologies and tailored biomaterials leads to precise, multifunctional delivery systems.
- Significant advancements reported in both clinical applications and preclinical in vivo models for GU repair.
- Development of intelligent systems for enhanced bioactivity, stability, and sustained release.
Conclusions:
- Polysaccharide-based delivery systems are crucial for advancing regenerative therapies in the lower GU tract.
- Smart delivery technologies and bioresponsive platforms are key to overcoming previous limitations.
- Future developments in materials, 3D printing, and engineering promise improved management of GU disorders.
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