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Updated: Jan 11, 2026
Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
Proteomic Profiling Reveals Mitochondrial Dysregulation in Rapidly Progressive Alzheimer's: Role of DLDH in Amyloid
Saima Zafar1,2, Aneeqa Noor3, Neelam Younas4
1Department of Neurology, Clinical Dementia Centerand, DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, Goettingen, 37075, Germany. saima.zafar@med.uni-goettingen.de.
Abstract:
Alzheimer's disease (AD) is presented as multiple clinical variants depending upon the rate of progression and familial background; however, the exact molecular mechanisms associated with these subtypes and their treatments are yet to be understood. The current study is based on a global proteome analysis of brain samples from patients (n = 38) with rapidly progressive AD (rpAD-survival time < 3 years), sporadic AD (spAD-survival time of 8-10 years), and healthy controls. Proteome analysis revealed a differential regulation of 79 proteins and highlighted the dysregulation of mitochondrial machinery and glucose metabolism in rpAD. Dihydrolipoamide dehydrogenase (DLDH), a mitochondrial oxidoreductase, showed a significant reduction and delocalization in rpAD. In vitro analysis revealed a potential role of DLDH in the aggregation of amyloid beta. Rapid progression in AD may be influenced by the energy homeostasis and redox dysfunction linked with the DLDH.
