Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 11, 2026

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.8K

Chronic Intermittent Hypoxia Exposure Induces a Unique Microglial Transcriptome in 5XFAD Mice.

Kaitlyn M Marino1,2, Andrea C Ewald3, Jaidynne N Lash2,3

  • 1Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA.

Molecular Neurobiology
|November 19, 2025
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

uPAR exhibits age- and region-dependent expression in the brains of mice with Alzheimer's disease-like pathology.

Brain research·2026
Same author

Type-1 interferons associated with microglial-mediated neuroinflammation in Alzheimer's disease.

Journal of neuroinflammation·2026
Same author

Montelukast suppresses NLRP3 inflammasome activation as a potential prophylactic agent against gout arthritis flares.

Journal of inflammation (London, England)·2026
Same author

Neonatal inflammation induces lasting sex- and region-dependent microglia activation and sex-dependent impairments in chemoreflexes.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Verteporfin attenuates NLRP3 inflammasome activation to alleviate gout arthritis flares.

Journal of inflammation (London, England)·2025
Same author

Estrogen Enhances SK Channel Activity to Limit Hippocampal Arteriole Constriction.

Circulation research·2025
Same journal

Glucocorticoid Signaling in PSC-Derived Neural Systems to Elucidate Mechanisms of Stress-Induced Psychiatric Vulnerability.

Molecular neurobiology·2026
Same journal

Curcumin Attenuates Cuproptosis via Activating Autophagy Through Inhibition of the AKT/mTOR/P70S6K-Signaling Pathway in Parkinson's Disease Models.

Molecular neurobiology·2026
Same journal

Chronic Lithium Exposure Reshapes PI3K-mTOR-linked Proteostatic Networks in the Hippocampus of an Alzheimer's Disease Mouse Model.

Molecular neurobiology·2026
Same journal

Scientific Interest and Publication Patterns in Odontoblast-Neuron Crosstalk Research Related to Dentinal Hypersensitivity: A Bibliometric and Altmetric Review.

Molecular neurobiology·2026
Same journal

Microplastic-Induced Disruption of Intestinal Barrier Integrity and Triggering Neuroinflammatory Responses Through Gut-Brain Axis Dysregulation Mediated by NF-κB/PPAR-γ/BDNF Signalling Pathways.

Molecular neurobiology·2026
Same journal

Dissecting PANoptosis in the Nervous System: A Unified Cell-Death Mechanism Driving Neuroimmune Activation and Chronic Neuroinflammation.

Molecular neurobiology·2026
See all related articles
This summary is machine-generated.

Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) may interact. Chronic intermittent hypoxia (CIH) robustly altered microglial gene expression in AD mice, suggesting metabolic changes drive this synergy.

Area of Science:

  • Neuroscience
  • Pathology
  • Genomics

Background:

  • Clinical observations link obstructive sleep apnea (OSA) and Alzheimer's disease (AD).
  • Causal mechanisms between amyloidosis and intermittent hypoxia (IH), a hallmark of OSA, remain unclear.
  • Investigating the interplay between OSA and AD is crucial for understanding neurodegenerative disease progression.

Purpose of the Study:

  • To investigate the potential interaction between amyloidosis and chronic intermittent hypoxia (CIH) in a mouse model of AD.
  • To explore the effects of CIH on microglial gene expression in the context of AD pathology.
  • To identify potential molecular mechanisms underlying the synergy between OSA and AD.

Main Methods:

  • 5XFAD mice, a model for AD, were exposed to chronic intermittent hypoxia (CIH) or normoxia (NX).
Keywords:
AmyloidIntermittent hypoxiaMicrogliaNeuroinflammation

More Related Videos

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.4K
Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
07:07

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

6.5K

Related Experiment Videos

Last Updated: Jan 11, 2026

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.8K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.4K
Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
07:07

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

6.5K
  • Amyloid burden, astrocyte, and microglia counts were assessed.
  • Bulk RNA sequencing was performed on isolated microglia to analyze gene expression changes.

    • Main Results:

    • CIH did not significantly alter amyloid burden or astrocyte numbers in 5XFAD mice.
    • A slight decrease in microglia was observed in the cortex of CIH-exposed 5XFAD mice.
    • CIH induced more significant gene expression changes in microglia from 5XFAD mice compared to wild-type (WT) mice, particularly in males.
    • Upregulated genes in CIH-exposed 5XFAD mice were enriched in pathways related to cellular respiration and ATP synthesis.

    Conclusions:

    • CIH has a more pronounced effect on the microglial transcriptome in 5XFAD mice than in WT mice.
    • Metabolic changes in microglial gene expression may underlie the synergistic effects of OSA and AD pathologies.
    • Sex differences in response to CIH were observed, mirroring human disease patterns.