Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

166
Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
166
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

387
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
387
Strategies of Self-Presentation I: Strategic Self-Presentation01:12

Strategies of Self-Presentation I: Strategic Self-Presentation

183
Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
183
Social Proof00:52

Social Proof

31.4K
Social proof is a form of persuasion based on comparison and conformity. People compare their behavior and actions to what others are doing and will change to conform to do what their peers do.
31.4K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

212
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
212
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

860
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
860

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural disasters and suicidality in Australia: a systematic review.

Social psychiatry and psychiatric epidemiology·2026
Same author

Widespread synaptic density loss in schizophrenia follows molecular and network architecture.

Molecular psychiatry·2026
Same author

Laser treatment of hypertrophic scars: the operative and peri-operative practices of burns clinicians.

Lasers in medical science·2026
Same author

The way we do things matters: the deep integration of lived experience in the a/part of the crowd project to respond to loneliness in young adults.

Research involvement and engagement·2026
Same author

Do virtual reality-based therapies affect symptomatology and psychosocial functioning in schizophrenia spectrum disorders: systematic review and meta-analysis.

BJPsych open·2026
Same author

Effects of glucagon-like peptide-1 receptor agonists on anthropometric and adiposity measures in patients with antipsychotic-induced weight gain: A systematic review and meta-analysis.

Journal of psychopharmacology (Oxford, England)·2026
Same journal

Sparse multi-way DMDC for longitudinal classification in high dimension low sample size data.

BMC medical research methodology·2026
Same journal

Tree-based exploratory identification of predictive biomarkers in non-randomized data.

BMC medical research methodology·2026
Same journal

Comparative evaluation of interrupted time series analytical methods for healthcare quality improvement research: a Monte Carlo simulation study.

BMC medical research methodology·2026
Same journal

Methodological advances in claims-based dementia algorithms: integrating medication and clinical data for medicare populations.

BMC medical research methodology·2026
Same journal

An interpretable XGboost algorithm for predicting 30-day mortality in acute pancreatitis using routine biomarkers.

BMC medical research methodology·2026
Same journal

Increasing power and robustness in screening trials by testing stored specimens in the control arm.

BMC medical research methodology·2026
See all related articles

Related Experiment Video

Updated: Jan 11, 2026

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.6K

Could master protocols be adapted for effectiveness-implementation hybrid studies?

Justin J Chapman1,2,3,4, Taren Massey-Swindle5,6,7, Urska Arnautovska8,9,10

  • 1Griffith University, Centre for Mental Health, School of Pharmacy and Medical Science, 170 Kessels Road, Nathan, Brisbane, QLD, 4111, Australia. justinjchapman@gmail.com.

BMC Medical Research Methodology
|November 19, 2025
PubMed
Summary
This summary is machine-generated.

Master protocols can be adapted for effectiveness-implementation hybrid studies, accelerating the translation of research into real-world practice. Further testing is needed to confirm their feasibility in routine care settings.

Keywords:
Co-designDisseminationEffectiveness-implementation hybridExternal validityMaster protocolsPlatform trialsPragmatic trialsResearch capacity buildingResearch methodologyResearch networkResearch partnershipTWiCsTranslational researchTrial networkTrials within cohorts

More Related Videos

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
10:26

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities

Published on: September 11, 2021

4.3K
Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
08:27

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits

Published on: September 27, 2019

7.2K

Related Experiment Videos

Last Updated: Jan 11, 2026

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.6K
Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
10:26

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities

Published on: September 11, 2021

4.3K
Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
08:27

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits

Published on: September 27, 2019

7.2K

Area of Science:

  • Translational Science
  • Implementation Science
  • Clinical Trial Design

Background:

  • Master protocols streamline multi-study clinical trials using a shared infrastructure.
  • Translational research bridges scientific discovery and public health impact by assessing intervention efficacy and real-world effectiveness.
  • The application of master protocols to effectiveness-implementation hybrid studies remains underexplored.

Purpose of the Study:

  • To develop recommendations for adapting master protocol methodologies for effectiveness-implementation research.
  • To explore how master protocols can support hybrid effectiveness-implementation sub-studies.
  • To provide a framework for integrating implementation science within master protocol designs.

Main Methods:

  • Consultation with translational research networks from January to December 2024.
  • Analysis of requirements for service providers in translational research.
  • Review of implementation frameworks to inform protocol adaptations.

Main Results:

  • Recommendations cover common trial infrastructure, hypotheses, data collection, control groups, adaptive elements, and eligibility criteria.
  • Leveraging cross-sectoral partnerships and co-produced research accelerates the translational pipeline.
  • Adaptive elements within master protocols enhance the efficiency of effectiveness-implementation studies.

Conclusions:

  • Adapting master protocols for hybrid studies can improve the implementation of evidence-based interventions in routine care.
  • The feasibility of master protocols for effectiveness-implementation research requires further investigation.
  • Testing the proposed methodology is essential for advancing implementation science within master protocols.