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Updated: Jan 11, 2026
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Preparation and Morphological Analysis of Chick Cranial Neural Crest Cell Cultures
Published on: June 27, 2022
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Lineage Analysis of Pallial Subdivision-Derived Cells in the Developing Chick Pallium
Kyosuke Wada1,2, Ryoka Katayama1,3,4, Illia Aota1
1Developmental Neuroscience Project, Department of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Development, Growth & Differentiation
|November 19, 2025
Summary
Bird brain development shows cells migrate across regions, challenging the idea that identical cells always come from the same area. This finding impacts understanding of avian pallium and telencephalon development.
Area of Science:
- Neuroscience
- Developmental Biology
- Comparative Anatomy
Background:
- The avian pallium, unlike the six-layered mammalian telencephalon, has distinct nuclear regions.
- It's unknown if cells with similar gene expression profiles originate from the same developmental region.
Purpose of the Study:
- To investigate avian cell lineages and migration patterns.
- To determine if cells with identical features arise from the same progenitor regions.
Main Methods:
- Utilized the integration-coupled gene expression On (iOn) switch for lineage tracing.
- Employed whole-brain light-sheet fluorescence microscopy (LSFM) for imaging.
Main Results:
- Cells born in specific avian pallial regions migrate across different areas.
- Identical cell characteristics are not exclusively linked to the same progenitor regions.
- Early cell migration in the dorsal ventricular ridge follows radial fibers, but this is not required for later stages.
Conclusions:
- Findings support developmental convergence models for cell lineage.
- Avian pallial development involves significant inter-regional cell migration.
- Cell migration mechanisms show both conserved and divergent features compared to mammals.
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