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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
A Rare Shift From Hypothyroidism to Hyperthyroidism: The Unusual Thyroid Journey After Hematopoietic Stem Cell
Jennie Kit-Yee Wong1, Joanna Yuet-Ling Tung, Sarah Wing-Yiu Poon
1From the Department of Paediatrics and Adolescent Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong Special Administrative Region, China.
Abstract:
Thyroid dysfunction is a well-recognized complication following hematopoietic stem cell transplant, com-monly manifested as nonimmune hypothyroidism secondary to chemotherapy and total body irradiation. Autoimmune thyroid diseases, including Graves disease and Hashimoto thyroiditis, are uncommon. Sequential development of hypothyroidism and hyperthyroidism after hematopoietic stem cell transplant is extremely rare and has only been reported in isolated case reports. We present 2 pediatric cases of this transition and explore the possible pathophysiological mechanisms and implications for long-term endocrine surveillance in hematopoietic stem cell transplant survivors.
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