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Acute Salt Poisoning Leading to Subarachnoid Hemorrhage: A Case Report
Ichiro Hirayama1,2, Takumi Akiyama2, Tatsuhiko Hayashi1,2
1Department of Clinical Toxicology, Faculty of Medicine Saitama Medical University Saitama Japan.
Clinical Case Reports
|November 19, 2025
Summary
Severe hypernatremia and brain hemorrhage from soy sauce ingestion can be treated successfully. Rapid, controlled correction of high serum sodium levels led to full neurological recovery in this case.
Area of Science:
- Neurology
- Toxicology
- Internal Medicine
Background:
- Severe hypernatremia is a critical condition often associated with poor neurological outcomes.
- Salt poisoning, particularly from ingesting large volumes of high-sodium substances like soy sauce, can precipitate serious medical emergencies.
- Intracranial hemorrhage, including subarachnoid hemorrhage, is a known but rare complication of severe hypernatremia.
Purpose of the Study:
- To report a case of severe hypernatremia and subarachnoid hemorrhage secondary to massive soy sauce ingestion.
- To illustrate the successful management and favorable neurological outcome following rapid, controlled correction of hypernatremia.
- To highlight the potential for recovery in salt poisoning-induced intracranial hemorrhage.
Main Methods:
- A 51-year-old male patient presented with severe hypernatremia (171 mEq/L) and nonaneurysmal subarachnoid hemorrhage after ingesting 1 liter of soy sauce.
- Treatment involved the administration of 5% dextrose for controlled reduction of serum sodium levels.
- Careful monitoring was implemented to avoid hyperglycemia during the correction process.
Main Results:
- The patient's serum sodium levels were rapidly and effectively corrected.
- Hyperglycemia was successfully avoided throughout the treatment period.
- The patient achieved full neurological recovery, with resolution of symptoms related to hypernatremia and subarachnoid hemorrhage.
Conclusions:
- This case demonstrates that aggressive, yet controlled, correction of severe hypernatremia is feasible and can lead to excellent neurological outcomes, even in the presence of intracranial hemorrhage.
- Salt poisoning is a significant risk factor for both hypernatremia and subsequent neurological complications, including hemorrhage.
- Prompt and appropriate medical intervention can reverse the effects of salt poisoning and improve patient prognosis.
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