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Updated: Jan 11, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Susceptibility and resistance of Gram-negative bacteria to a novel antimicrobial agent TGV-49
Victor V Tetz1, Kristina M Kardava1, Maria F Vecherkovskaya1
1Department of Systems Biology, Human Microbiology Institute, New York, NY, United States.
Introduction:
Antimicrobial resistance remains a major global public health challenge that necessitates novel drugs with a low resistance rate.
Methods:
Herein, we evaluate TGV-49, a novel broad-spectrum antimicrobial agent, against multidrug-resistant Gram-negative bacteria, including ESKAPE pathogens (Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae) and pathogens from agriculture that infect humans (Ralstonia solanacearum and Aeromonas hydrophila).
Results:
TGV-49 was highly effective in overcoming resistance to conventional antibiotics. The experimental evolution of A. baumannii using a morbidostat revealed minimal development of resistance.
Conclusion:
Our findings suggest TGV-49 as a potential alternative for combating MDR infections in clinical and agricultural settings.
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