Clinicopathologic Study of Oral Mucosa-Derived Hamartomas and Choristomas and Literature Review

This study aimed to investigate the sociodemographic and clinicopathological data of oral soft tissue hamartomas and choristomas. A cross-sectional study was delineated to quantitatively analyze oral soft tissue hamartomas and choristomas cases diagnosed between 1978 and 2025 in a Brazilian Oral Pathology Service. The patient's file raised data regarding the clinical parameters, demographic data, diagnostic imaging, and histopathological features. A review of case reports published in the literature was also performed, analyzed, and compared to our casuistic. Fifteen cases were retrieved from our archive: 60.00% hamartomas and 40.00% choristomas. Females were more affected than males (53.33% vs. 46.67%). The ages of the affected patients varied from newborns to older people. Clinically, most of the lesions were nodular, had an oral mucosa-like color, and were painless. The buccal gingiva was the most prevalent region affected by the lesions (53.33%). All cases were treated by surgery. Although uncommon, oral soft tissue hamartomas and choristomas mainly affect people of different ages, from newborns to older people. They should be diagnosed promptly to offer better therapeutic management, avoiding invasive treatments that contradict their benign nature.