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Emerging biomarkers for gestational diabetes mellitus and related pediatric outcomes

Tanu Gautam1, Amreen Shamsad1, Renu Singh2

  • 1Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow 226007, Uttar Pradesh, India.

World Journal of Clinical Pediatrics
|November 19, 2025
PubMed

Insights

Gestational diabetes mellitus (GDM) diagnosis is improving with novel biomarkers like microRNAs and gut microbiota. These advancements aid in early prediction and personalized management, enhancing feto-maternal health outcomes.

Area of Science:

  • Reproductive Medicine
  • Metabolic Disorders
  • Biomarker Discovery

Background:

  • Gestational diabetes mellitus (GDM) is a pregnancy complication linked to maternal and infant metabolic health issues.
  • Current GDM diagnostic methods have limitations, necessitating improved early detection strategies.
  • Adverse feto-maternal outcomes are associated with GDM, highlighting the need for timely intervention.

Purpose of the Study:

  • To review emerging biomarkers for gestational diabetes mellitus (GDM) diagnosis and prediction.
  • To evaluate the diagnostic accuracy and predictive value of novel GDM biomarkers.
  • To explore the clinical applications of these biomarkers for personalized medicine approaches in GDM management.

Main Methods:

  • Literature review of recent research on GDM biomarkers.
  • Analysis of emerging biomarkers including microRNAs, cell-free DNA, exosomes, and gut microbiota.
  • Examination of advanced technologies like next-generation sequencing, metabolomics, and proteomics in biomarker discovery.

Main Results:

  • Novel biomarkers such as microRNAs, cell-free DNA, and gut microbiota show promise for GDM diagnosis.
  • Emerging biomarkers offer potential for earlier prediction of GDM and associated pediatric outcomes.
  • Advanced omics technologies facilitate the identification and validation of new GDM biomarkers.

Conclusions:

  • Emerging biomarkers represent a significant advancement in GDM diagnostics and prediction.
  • Personalized medicine approaches utilizing novel biomarkers can improve feto-maternal outcomes.
  • Further research is warranted to translate these biomarkers into clinical practice for GDM management.

Keywords:
Emerging biomarkersGestational diabetes mellitusInsulin resistancePediatric outcomesPersonalized medicine

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