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Related Experiment Video

Updated: Jan 11, 2026

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation

Published on: September 2, 2025

NP-guide: a portable projection-based navigation system for neurosurgery and beyond.

Zhongjie Shi^1,2, Xin Gao¹, Sifang Chen¹

¹Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Frontiers in Neurology

|November 19, 2025

Summary

The Navigation and Projection Guide (NP-Guide) offers a portable, accurate, and efficient augmented reality (AR) solution for neurosurgical localization. This projection-based system shows promise for improving surgical navigation, especially in resource-limited environments.

Keywords:

NP-guide augmented reality neurosurgery proof-of-concept study surgical navigation

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Last Updated: Jan 11, 2026

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Published on: September 2, 2025

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Published on: May 24, 2024

A Spine Robotic-Assisted Navigation System for Pedicle Screw Placement

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Published on: May 11, 2020

Area of Science:

Neurosurgery
Medical Technology
Augmented Reality

Background:

Existing stereotactic and robot-assisted neurosurgery systems offer high precision but are costly and complex for routine use.
There is a need for more accessible and practical surgical navigation solutions.
This study introduces the Navigation and Projection Guide (NP-Guide), an augmented reality (AR) system.

Purpose of the Study:

To evaluate the accuracy, efficiency, and reproducibility of the NP-Guide system.
To compare NP-Guide with traditional freehand localization methods.
To assess the potential of NP-Guide as a portable and accessible surgical navigation tool.

Main Methods:

A proof-of-concept study involving 52 neurosurgical patients randomized into NP-Guide and freehand groups.
Localization error and operating time were measured using an optical navigation system (ONS).
Bland-Altman analysis and learning curves were used to assess inter-operator agreement and proficiency.

Main Results:

The NP-Guide group demonstrated significantly improved accuracy (mean error 3.4–4.1 mm) and efficiency (mean time 1.1–1.2 min) compared to freehand localization (p < 0.001).
Good inter-operator agreement was observed (p = 0.25).
Operating times plateaued around 1 minute after approximately 15 cases.

Conclusions:

The NP-Guide system provides accurate, efficient, and reproducible projection-based localization.
Its portability, cost-effectiveness, and ease of use make it a valuable tool, particularly in resource-limited settings.
Further multicenter studies are needed to validate these preliminary findings for routine clinical adoption.