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Impact of Polyphenolic Compounds on the MAPK Signaling Pathway against Carcinogenesis

Adem Keskin1

  • 1Department of Medicine Biochemistry, Aydın Adnan Menderes University, Institute of Health Sciences, Aydın, Türkiye.

Journal of Clinical Practice and Research
|November 19, 2025
PubMed

Insights

Polyphenolic compounds can regulate the mitogen-activated protein kinase (MAPK) signaling pathway, a key player in cancer development. This review explores their potential for cancer treatment by targeting this crucial pathway.

Area of Science:

  • Molecular Biology
  • Oncology
  • Nutritional Science

Background:

  • The mitogen-activated protein kinase (MAPK) signaling pathway is integral to cellular functions and its dysregulation is linked to various stages of carcinogenesis.
  • Aberrant MAPK signaling contributes to cancer progression, including metastasis, angiogenesis, and uncontrolled proliferation.
  • The MAPK pathway offers molecular targets for cancer intervention, with dietary polyphenols showing promise in modulating its activity.

Purpose of the Study:

  • To highlight the critical role of the MAPK signaling pathway in carcinogenesis.
  • To emphasize the therapeutic potential of dietary polyphenols in regulating MAPK signaling for cancer prevention and treatment.

Main Methods:

  • Literature review of studies investigating the role of polyphenols in modulating the MAPK signaling pathway.
  • Analysis of research on the anti-cancer effects of polyphenols through MAPK pathway regulation.
  • Examination of the clinical efficacy of polyphenolic compounds in cancer therapy.

Main Results:

  • Polyphenols from various dietary sources demonstrate significant ability to regulate the MAPK signaling pathway.
  • These compounds exhibit anti-cancer properties by inducing apoptosis, inhibiting angiogenesis, and suppressing tumor growth.
  • Promising outcomes from numerous studies suggest clinical efficacy in cancer management.

Conclusions:

  • The MAPK signaling pathway is a significant target in cancer therapy.
  • Dietary polyphenols represent a promising class of compounds for regulating the MAPK pathway and combating cancer.
  • Further clinical research is warranted to establish the full therapeutic potential of polyphenols against cancer.
Keywords:
MAPK signaling pathwaycancercarcinogenesispolyphenolstumor

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