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Dialysis Requirements of Kidney Transplant Recipients During COVID-19

Cihan Uysal1, Tuğba Yılmaz1, Sümeyra Koyuncu2

  • 1Department of Nephrology, Erciyes University Faculty of Medicine, Kayseri, Türkiye.

Journal of Clinical Practice and Research
|November 19, 2025
PubMed

Insights

Coronavirus Disease 2019 (COVID-19) significantly increases acute kidney injury (AKI) risk in kidney transplant recipients (KTR). Age, anemia, and reduced baseline kidney function predict severe AKI and dialysis needs in these patients.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Infectious Diseases

Background:

  • Kidney transplant recipients (KTR) face increased Coronavirus Disease 2019 (COVID-19) complications due to immunosuppression and comorbidities.
  • Acute kidney injury (AKI) is a common complication of COVID-19, particularly in vulnerable populations like KTR.

Purpose of the Study:

  • To investigate the impact of COVID-19 on kidney allograft survival in KTR.
  • To identify predictors of AKI and dialysis requirements in KTR following SARS-CoV-2 infection.

Main Methods:

  • Retrospective, single-center study of 88 KTR with functioning kidney allografts diagnosed with COVID-19.
  • SARS-CoV-2 infection confirmed via PCR and CT scans.
  • Analysis of demographic, clinical, and laboratory parameters, including AKI and dialysis needs.

Main Results:

  • 70.4% of KTR developed AKI, with 10.2% requiring dialysis.
  • Clinical features and inflammatory markers did not significantly predict dialysis needs.
  • Logistic regression identified serum protein, albumin, hemoglobin, baseline eGFR, and age as significant predictors of dialysis requirements.

Conclusions:

  • Age, anemia, and decreased baseline estimated glomerular filtration rate (eGFR) are associated with severe AKI and dialysis therapy in KTR during COVID-19.
  • These factors are crucial for risk stratification and management of KTR with COVID-19.
Abstract

Keywords:
Acute kidney injuryCOVID-19dialysiskidney transplantationmortality

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