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Updated: Jan 11, 2026

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
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Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

Published on: February 25, 2016

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Nuclear BIN1 isoforms regulate c-Myc-mediated cell cycle control in oligodendrocytes.

Iris Wai-Ting Ma, Gerald Wai-Yeung Cheng, Sunny Hoi-Sang Yeung

    Biorxiv : the Preprint Server for Biology
    |November 19, 2025
    PubMed
    Summary

    Bridging integrator 1 (BIN1) protein dysregulation in oligodendrocytes (OLs) is linked to Alzheimer's disease (AD). Nuclear BIN1 isoforms regulate OL cell cycle, and their altered expression contributes to myelin pathology in AD.

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